World Journal of
Pharmaceutical and Life Sciences

FERROPTOSIS WITH CHEMOTHERAPY: A SYNERGISTIC APPROACH TO CANCER THERAPY

*Sanket Kharwal, Chaudhary Dipali, Chaudhary Diya, Deep Prajapati, Baga Mohammad

ABSTRACT

Iron-dependent lipid peroxidation drives ferroptosis, a unique type of controlled cell death that has attracted a lot of interest due to its potential as a treatment for cancer and other illnesses. Ferroptosis, in contrast to apoptosis and necrosis, is distinguished by oxidative stress, disruption of lipid metabolism, and iron overload, providing a new way to target cancers that are resistant to treatment. The molecular processes behind ferroptosis are examined in this article, with particular attention paid to important inducers and inhibitors, including both natural and artificial substances. It also explores the possibility for synergy between ferroptosis inducers and traditional treatments like immunotherapy and chemotherapy, emphasizing their ability to boost therapeutic efficacy and go past resistance. Notwithstanding these encouraging advancements, problems with medication specificity, off-target effects, and tumour heterogeneity still exist, highlighting the need for creative fixes including patient classification based on biomarkers and sophisticated drug delivery methods. The importance of clinical trials in converting preclinical results into successful medicines is also emphasized in this article. All things considered, ferroptosis is a revolutionary new area in personalized medicine that might change cancer treatment and other fields.

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