World Journal of
Pharmaceutical and Life Sciences

ULTRASOUND-ASSISTED MAGNETO-PELLETIZATION (UAMP): A NOVEL APPROACH IN PHARMACEUTICAL PELLETIZATION

*Divyesh Prashant Gahivad, Ketan Sunil Patil, Shyam Sanjay Patil, Yash Anil Chaudhari, Lokesh Devidas Chaudhari and Nazeer Ahmed

ABSTRACT

Pelletization is a key pharmaceutical process aimed at producing spherical, multi-particulate drug delivery systems that offer advantages such as improved flow properties, controlled drug release, and enhanced bioavailability. Traditional methods like extrusion-spheronization, spray drying, and hot melt extrusion have limitations, including thermal stress and poor uniformity. This review highlights a novel approach — Ultrasound-Assisted Magneto-Pelletization (UAMP) — which combines ultrasound energy for particle dispersion and magnetic field manipulation for pellet shaping. UAMP has demonstrated potential for generating highly uniform, thermally stable, and flow-optimized pellets with superior drug loading and minimal binder use. Additionally, the article compares conventional pelletization techniques, discusses their mechanisms, and evaluates key formulation and process variables that influence pellet quality. The innovation and feasibility of

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