World Journal of
Pharmaceutical and Life Sciences

ROLE OF C-REACTIVE PROTEIN LEVEL AS A BIOMARKER FOR SEVERITY ASSESSMENT IN DENGUE FEVER IN DISTRICT COMBINED HOSPITAL, NOIDA, INDIA

Dr. Tapas Tripathi*, Dr. Renu Agrawal and Dr. Anurag Sagar

ABSTRACT

Objective: Dengue fever is a mosquito-borne viral infection that affects millions of individuals worldwide. Timely
identification of severe dengue cases is critical for appropriate management and reducing mortality. This
prospective observational study aimed to assess the utility of C-reactive protein (CRP) as a biomarker for severity
assessment in dengue fever. Methods: A prospective observational study was performed on dengue patients
admitted to a district combined hospital, Noida, India. All patients of age above 18 years, diagnosed with dengue
were included in the study. The detailed laboratory parameters pertaining to dengue were recorded. CRP levels
were estimated and compared between groups i.e. severe and non-severe dengue. CRP cut-off value was detected
using the receiver-operator curve. Results: Totally 100 patients with a mean age of 40 years were included.
Among them, 12% of the patients suffered from severe dengue, 53% of the cases had non-severe dengue without
warning signs, and 35% had non-severe dengue with warning signs. The median CRP was significantly higher in
patients with severe dengue compared to patients with non-severe dengue (96.2 mg/dL vs. 5.3 mg/dL). Univariate
logistic regression analysis showed that the odd’s ratio (OR) of CRP was 1.053 (P≤0.001, 95% CI=1.029-1.078).
CRP at a cutoff value of 21.6 mg/L (0.929 AUC) had excellent sensitivity (100%) and specificity (81.6%) in
predicting severe dengue infection. Conclusions: CRP level could be used as a potential biomarker to predict
severity of dengue in adults.

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