World Journal of
Pharmaceutical and Life Sciences

DYSLIPIDEMIC FACTORS IN FEMALE SMOKERS-A STUDY AT TERTIARY CARE HOSPITAL FROM NORTH INDIA

Premshanker Singh*, Ajay Misra, MS Siddique, Nikhil Gupta and DP Singh

ABSTRACT

Aim of present study was to determine the relationship between smoking and lipid related indices in Indian women smokers Smoking is a major risk factor for dyslipidemia. However, it remains to be clarified whether light smoking in Asian women affects lipid profiles and lipid-related indices. Alcohol drinking influences blood lipid levels and is a potent confounder for the relationship between smoking and blood lipids. Thus, analysis for the relationships between smoking and blood lipid-related indices was also performed after stratification of drinking statusThe participants were 18,79 Indian women aged 35–75 years who were smokers and reporting to Medical OPD(MOPD) of Dr RML Institute of Medical Sciences, Lucknow, India=22601. The relationships of smoking with each index were investigated by using analysis of covariance and logistic regression analysis with adjustment for age and other lifestyle factors such as alcohol drinking and regular exercise In multivariate logistic regression analysis, odds ratios of smokers vs. nonsmokers for high ratio of LDL cholesterol to HDL cholesterol (LDL-C/HDL-C), high ratio of triglycerides to HDL cholesterol (TG/HDL-C), high lipid accumulation product (LAP) and high cardio metabolic index (CMI) were significantly higher than the reference level of 1.00 in overall participants (2.17 [1.78–2.66], 1.70 [1.47–1.97], 1.17 [1.08–1.27] and 1.41 [1.30–1.53], respectively), nondrinking participants (2.29 [1.80–2.91], 1.68 [1.39–2.02], 1.21 [1.08–1.36] and 1.46 [1.30–1.63], respectively), and drinking participants (1.96 [1.35–2.85], 1.76 [1.39–2.21], 1.13 [1.01–1.27] and 1.38 [1.22–1.55], respectively). In overall participants, nondrinking participants and drinking participants, LDL-C/HDL-C, TG/HDL-C, LAP and CMI were significantly higher in smokers than in nonsmokers except HDL-C which was lower in smoker than nonsmoker. In nondrinking participants, triglycerides and LDL cholesterol were significantly higher in smokers than in nonsmokers, while the ratio of waist circumference to height and HDL cholesterol were significantly lower in smokers than in nonsmokers In women, all of the lipid-related indices eg Total Cholesterol(TC),HDL Cholesterol(HDL-C),Low Density Lipid Cholesterol(LDL-C),Very Low Density Lipid Cholesterol(VLDL-C) and Triglyceride Cholesterol(TGC) tested were higher in smokers than in nonsmokers and these associations were independent of alcohol drinking. The high levels of the lipid-related indices in smokers result from the detrimental effects of smoking on levels of blood lipids such as triglycerides, HDL cholesterol and LDL cholesterol.

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