World Journal of
Pharmaceutical and Life Sciences

EFFECTS OF RHEUM EMODI ON HALOPERIDOL INDUCED PARKINSONISM BY USING DESPIRE SWIM TEST

Pooja R. Ganeshkar*, Sachin J. Dighade and Anjali M. Wankhade

ABSTRACT

In this study, effects of rheum emodi (100, 200, and 400 mg/kg, p.o.) were studied using in vivo behavioral parameters like catalepsy, locomotor activity, muscles coordination and its effects in rats. The experiment was designed by giving haloperidol to induce catalepsy and Parkinson’s disease-like symptoms. The increased cataleptic scores (induced by haloperidol) were significantly (???? < 0.001) found to be reduced, with the EERE at a dose of 200 and 400 mg/kg. Significantly induced motor dysfunction (muscle rigidity and hypolocomotion). Daily administration of EERE (400 mg/kg) significantly improved motor performance and also significantly attenuated oxidative damage. In the present study, we evaluated anti-Parkinson’s activity of Ethanolic extract of Rheum emodi (EERE) leaves in haloperidol induced catalepsy in experimental animal models. Thus, the study proved that Rheum emodi treatment significantly attenuated the motor defects and also protected the brain.

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