World Journal of
Pharmaceutical and Life Sciences

INVESTIGATIONS OF ANALGESIC, ANTIDIARRHEAL AND CNS EFFECTS OF SCOPARIA DULCIS

*Yesmin Begum, Israt Jahan Bulbul, Khandoker Sadia Ferdousi

ABSTRACT

Synthetic drugs are widely used for the management of pain, inflammation, diarrhea and anxiety that carry severe toxic effects. Globally research and trials are ongoing to establish novel medicinal plants to introduce effective and economic drugs. The study was focused to investigate the analgesic, antidiarrheal and CNS effects of ethanolic leaf extract of Scoparia dulcis (Family: Scrophulariaceae) in Swiss albino mice. The analgesic activity was investigated by using acetic acid induced writhing, tail immersion and eddy’s hot plate method. Castor oil induced diarrheal models were used to evaluate antidiarrheal property. CNS effects were observed by conducting hole cross, open field, hole board and rota rod methods. All studies were carried out in mice at the doses of 50mg/kg and 100mg/kg body weight. The results of the present investigation indicate that the extract displayed significant (P < .001) analgesic activity and showed maximum writhing inhibition (58.33%) at the dose of 100 mg/kg body weight compared to standard drug indomethacin in acetic acid induced writhing method. The leaf extract also showed statistically significant (P < .001) dose dependent reduction of pain in both tail immersion and eddy’s hot plate method with 49.28% and 100% pain inhibition at 1 hour compared to standard drug. In castor oil induced diarrhea method, the extract showed significant (P<.001) antidiarrheal activity (100%) at the dose of 100mg/kg body weight compared to standard drug loperamide. The extract also showed sedative effects in hole cross, open field and hole board methods with 52.5%, 47.93% and 73.85% of movement inhibition respectively whereas in rota rod falling time decreases with 30.44% at 100mg/kg dose compared to standard drug. The investigated study concludes that the leaf extract has central as well as peripheral analgesic, antidiarrheal and sedative effects which support a significant scope to develop its medicinal practice.

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