World Journal of
Pharmaceutical and Life Sciences

INVITRO ANTIMICROBIAL ACTIVITY OF PHYTOCHEMICAL EXTRACT OF MYRISTICA FRAGRANS ON STREPTOCOCCUS MUTANS

Nidhi Jaiswal*, and Dr. Shobha Shrivastava

ABSTRACT

The mouth is full of bacterial micro flora, it provides perfect atmosphere for microbial growth. Streptococcus mutans is considered as a potent caries causing bacteria and most common caries causing pathogen isolated from dental plaque. The aim of the study is to determine the invitro inhibitory potential of phytochemical extract of Myristica fragrans(its nuts) on S.mutans. Myristica fragrans is a spice plant that yields Nutmeg or Jaiphal, is common spice used by people. The method used for extraction of phytochemicals from nutmeg was soxlet extraction. Ethanolic and aquous extracts was obtained and used for used for testing its antimicrobial activity against S.mutans.The percentage yield so obtained was 64% and 34% respectively. The antimicrobial activity was performed by using well diffusion method. S.mutans was seeded on NAM(Nutrient agar media).Both aquous and ethanolic extract of M.fragrans was filled in wells of 6mm diameter on NAM plate and incubated at 37 degree C for 24 hrs.The recorded zone of inhibition was found out to be 20mm amd 29mm respectively. Thus this showed that Myristica fragrans is a potent antimicrobial against S.mutans which can be used in many formulations of mouthwashes, dental tubes atc as a potent constituent.

[Full Text Article]   [Download Certificate]