World Journal of
Pharmaceutical and Life Sciences

AN OVERVIEW OF NANOFIBERS IN DRUG DELIVERY SYSTEM

Shuhaib B.*, Junaid T. L., S. K. Neffi Rafiya and Fazna Nazeer

ABSTRACT

Nanofibers are a nanomaterial with one dimension less than 100 nm. Wide range of polymers such as polyvinyl alcohol, gelatin, collagen, chitosan and carboxymethylcelulose can be subjected to electro spinning technique, self assembly and phase seperation to produce nanofibers. Their unique porous structures and large surface to volume area make them suitable for a wide variety of applications.these nanofibers are characterised by geometrically, physically and chemically. Electrospinning provides the most versatile process to produce nanofibers with a wide range of properties. The advantages of employing electrospinning technology to prepare DDS are not as yet fully exploited. Nanotechnology is now having an impact in biotechnology, pharmaceutical and medical diagnostics sciences. Furthermore electro-spinning as noted before has gained more attention due in part to a surging interest in nanotechnology, as ultrafine fibers or fibrous structures of various polymers with small diameters. Potential medical applications include efforts to fabricate electrospun polymer nanofiber scaffolds for nerves, tissues, skin and bone. Still several problems must be resolved for further applications such as the drug loading, the initial burst effect, the residual organic solvent, the stability of active agents, and the combined usage of new biocompatible polymers.

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