World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), Web of Science Group (Under Process), Directory of Research Journals Indexing, Scholar Article Journal Index (SAJI), International Scientific Indexing ( ISI ), Scope Database, 



*Ohadoma S. C. and Eban L. K.


Objective: To access the role of electrolyte excretion in aminoglycoside renal demage using experimental rats. Methods: Six groups each comprising five glycerol-pretreated and non-glycerol-pretreated rats were employed. In the later, Group 1 served as control and received normal saline (1 ml/kg body weight) intraperitioneally (ip). Groups II, III, IV, V and VI received Netilmicin, gentamycin, frusemide, netilmicin + gentamycin, and netilmicin + frusemide ip respectively. While in the former (glycerols-pretreated ), Groups II, III, IV, V and VI received netilmicin, gentamycin, frusemide, netilmicin + gentamycin and netilmicin +gentamycin + frusemide ip respectively. Electrolytes were determine using EEL Model 920 chloride meter and EEL flame photometer for alkali metal ions in the urine samples. Reproducible data were analyzed with a digital Vax/Vms computer using Monitab programme for the one-way analysis of variance and student T-test. Results: in the non-glycerol pretreated animals, only those that received gentamicin excreted significantly (p?0.05) more urinary chloride, caused a slight increase in urinary potassium excretion, and increased the urinary excretion of sodium than the control. While in glycerol-pretreated animals, only those that received netilmicin + gentamycin showed similar urinary chloride excretion to the control but a marked increase in the urinary excretion of potassium in those that received netilmicin alone; and netilmicin produced a decrease (unlike gentamicin) in urinary sodium excretion. Conclusion: Renal excretion of electrolytes indicate progressive renal damage, yet its sensitivity was not high enough based on the large standard of error, as a biochemical parameter for measuring aminoglycoside nephrotoxicity.

[Full Text Article]


World Journal of Pharmaceutical and life sciences Will give best paper award in every issue in the from of money along with certificate to promote research .

Best Article of current issue

Download Article : Click here