World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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**Prof. (Dr.) Sudarsan Behera and *Dr. Sushanta Sahu


Osteoarthritis (OA) is the most common form of arthritis in human beings. It is the most prevalent and disabling amongst chronic diseases. The incidence increases with age. Approximately 80 percent of the population gets afflicted by the age of 65 yrs. Pain and limitation of movement restrict the independence of older adults by impairing their performance of activities in day to day living. As a result, dependence becomes common for ambulation, stair climbing and other lower-extremity functions. The precise etiology of osteoarthritis is unknown. The biochemical and biomechanical factors may play an important role in the etio-pathogenesis. OA can be classified as a primary (idiopathic) or secondary depending upon the absence or presence of an underlying local or systemic condition respectively. Secondary OA may develop at any age in a joint damaged by trauma, disease (such as tuberculosis, gout, RA), and deformity (such as congenital dislocation of the hip) Conversely, Primary OA is without discernable relation to any other disease process. It occurs mainly in middle-aged or elderly individuals & typically involves distal joints i.e. interphalangeal region of fingers (forming Heberden's nodes) But it may involve hip, knee, vertebral, and other joints.

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