REVIEW ON ROLE OF BBB AND ITS TRANSPORT MECHANISMS IN THE DEVELOPMENT OF BRAIN TARGETED DRUG DELIVERY SYSTEMS
The development of brain drug delivery system which can effectively administer drug into brain region has been very challenging for formulation scientists. The presence of highly selective blood brain barrier and tight junction of epithelial cell make the permeation of most drugs difficult. Many researchers have tried to utilize traditional approaches like prodrugs and temporary reversible disruption of blood brain barrier but they are not much effective. Recently the development in the field of nanotechnology has shown some promising results in terms of development of proper brain targeted drug delivery systems. The thorough understanding of underlying mechanism by which some substances are crossing BBB is very important to develop an effective brain targeted drug delivery system. In this review the focus of discussion is on the understanding of various mechanism and effective exploitations of valuable promising leads by which a drug can transport across the BBB to enter into the CNS.[Full Text Article]
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