World Journal of
Pharmaceutical and Life Sciences

FORMULATION DEVELOPMENT AND EVALUATION OF FLOATING TABLETS CONTAINING NIZATIDINE

Mander Harmeet Kaur*, Rajesh Kumari Patil, Hanumant Rao Patil and Sunita Rani

ABSTRACT

The main aim of this investigation was to develop a controlled release floating drug delivery system (tablet) of Nizatidine. Floating tablets of nizatidine were prepared to extend gastric residence time and hence to enhance its bioavailability. The floating matrix tablets were prepared by direct compression technique using a combination of hydroxyl propyl methyl cellulose K15M (HPMC K15M) and Karaya gum as polymers and sodium bicarbonate as generating agent. The prepared floating tablets were evaluated for weight variation test, hardness, thickness, swelling index, in vitro floating capabilities, floating lag time, compatibility studies, and in vitro drug release. The swellable hydrophilic natural karaya gum was used to control the release of drug. The results showed that the optimized formulation F5, F6, F7 & F8 had good floating capability, shorter floating lag time, and sustained drug release for the period of ?24 h. In the current study, it was also found that overall rate of drug release tends to decrease with increase in concentration of polymer. These observations are in agreement with the results reported in literature i.e. with the increase in polymer concentration or viscosity grade, the viscosity of gel layer around the tablet also increases leading to enhanced diffusion path length for the drug to follow and thus limits the release of active ingredient.

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