World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE MUCOADHESIVE TABLETS OF DILTIAZEM HYDROCHLORIDE FOR PROPHYLAXIS OF ANGINA PECTORIS

Vidhyabharathi Anbazhagan*, Elango K., Vivek Vincent and Daisy Chellakumari

ABSTRACT

The aim of the present study was to formulate and evaluate Gastroretentive sustained release mucoadhesive tablets of Diltiazem hydrochloride for the prophylaxis of Angina pectoris. The most common symptom of angina is feeling of pain or discomfort in chest caused by cardiac ischemia. Diltiazem is a potent calcium channel blocker acts by relaxing the muscles that make up the walls of the arteries, which increases blood supply to the heart. Preformulation studies showed excellent flow property. Tablets were prepared by direct compression method using Hydroxy Propyl Methyl Cellulose (HPMC) E 15 and HPMC K 15 as mucoadhesive polymers and Ethylcellulose (EC) as release retarding polymer. Uniformity of weight, hardness, thickness, diameter and friability were determined. Drug content for all the formulations was in the range of 90.66% to 99.83%w/w. In vitro release was performed in acid buffer pH 1.2. The drug release for the optimised batch (F4) was found to be 99.2% at the end of 23 hours. The sustained action was due to Ethylcellulose (10%). The swelling index was found to be 120%. The tablet swelled gradually and releases the drug slowly due to hydrophilic and high viscous nature of HPMC K15.

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