World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Dr. K. Saraswathi Gopal* and Dr. Prakash Vijayan Bhoopalan


The clinical presentation of any pathology in the oral cavity can alter the mucosal surface or submucosal structures. The diagnosis of such pathology depends on the history, examination, laboratory studies, biopsy and other diagnostic procedures. In 16th century, Sir Marcello Malphigi formulated the basic microscopic technique of utilizing the living tissues. He termed it Bios-living, Opsis-visualizing. Later, Sir Georianni Morgahni in the early 17th century popularized this method through his book ‘The site and causes of diseases’ which laid the foundation for physiologic anatomy.[1] The term "biopsy" was introduced into medical terminology in 1879 by Ernest Besnier.

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