World Journal of
Pharmaceutical and Life Sciences

FORMULATION AND EVALUATION OF ORAL MEDICATED JELLIES: A COMPARATIVE REVIEW OF SELECTED DRUGS

Avinash M.*, Gnanisha M., Parthasarathi V., C. Jenifer

ABSTRACT

Oral medicated jellies have emerged as a patient-friendly, palatable, and convenient alternative dosage form designed to improve compliance, particularly among pediatric, geriatric, and dysphagic populations. This review comprehensively discusses the formulation principles, polymers, gelling agents, sweeteners, preservatives, and evaluation parameters associated with medicated jellies, along with their advantages over conventional oral solid and liquid dosage forms. Key formulation components—including natural and synthetic polymers such as pectin, gelatin, Carbopol, and sodium alginate—are examined with respect to their gel-forming ability, stability, and compatibility with active pharmaceutical ingredients. The article highlights critical evaluation parameters such as organoleptic properties, pH, viscosity, gel strength, syneresis, drug content uniformity, and in-vitro release behaviour. Recent studies demonstrating improved bioavailability, rapid disintegration, ease of administration, and enhanced therapeutic outcomes with various drug categories are also summarized. Overall, oral medicated jellies represent a versatile and effective platform for delivering drugs that require improved palatability, faster onset of action, or alternative administration routes, with promising potential for future pharmaceutical innovation.

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