World Journal of
Pharmaceutical and Life Sciences

FORMULATION AND EVALUATION OF EMULGEL OF LULICONAZOLE AS TOPICAL DRUG DELIVERY SYSTEM

Bhupendra Singh, Ajay Patel, Nilesh Gupta and Umesh Kumar Jain*

ABSTRACT

The present studies are aimed to formulate and characterized emulgel of selected antifungal drugs luliconazole for
the rapid easy onset of action in the treatment of acne vulgarises or skin disorder and to improve the bioavailability
of the drug. Luliconazole being a BCS Class II drug has a low solubility and high permeability hence to increase
the solubility of drug an emulgel was formulated which also ensures patient compliance. Formulation of better
product than the currently marketed product, having better penetration and ultimately the efficacy of the final
formulation when compared with marketed product. Hypothesis of Polymeric emulsifiers will be evaluated to
convert unstable emulsion to a stable formulation with lower level of surfactant concentration. Formulation of
emulgel with incorporation of maximum concentration of oil phase up to 50%w/w with lowest concentration of
surfactants in aqueous phase can be done. The aim behind carrying out this research work is to formulate a stable
emulgel of a hydrophobic drug Luliconazole of 1.0 % for the treatment of Fungal Infections which enhance the
solubility and stability of Luliconazole.

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