World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

EFFECTS OF IRVINGIA WOMBOLU LEAF EXTRACT ON SERUM LIPID PROFILE AND HEPATIC BIOMARKERS IN MALE WISTAR RATS

*Olubunmi Olusoga Ezomoh, Wariebi Koikoibo, Nweke Chimamanda Frances

ABSTRACT

Despite the well-documented nutritional value of Irvingia wombolu seeds, limited research has explored the biochemical impact of its leaves. This study assessed the effects of aqueous leaf extract of Irvingia wombolu on lipid profile, total protein, albumin, and bilirubin levels in male Wistar rats. Twelve rats were randomly assigned into three groups: a control group receiving distilled water, and two treatment groups receiving 200 mg/kg and 400 mg/kg body weight of the extract orally for 28 days. Blood samples were collected on days 0, 1, 14, 21, and 28 to analyze serum lipid and hepatic biomarkers. The results showed no statistically significant changes (p < 0.05) in lipid parameters or hepatic biomarkers between control and treated groups, with all values remaining within normal physiological ranges. These findings suggest that Irvingia wombolu leaf extract is biochemically safe at the tested doses, although further research is needed to explore higher doses and longer durations for potential therapeutic effects.

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