World Journal of
Pharmaceutical and Life Sciences

A REVIEW ON THE IMMUNOMODULATORY AND HEPATOPROTECTIVE EFFECTS OF BUCHANANIA LANZAN SEED EXTRACT

Himanshu Singh Praveen Kumar, Nasiruddin Ahmad Farooqui*

ABSTRACT

Liver diseases are becoming a serious health problem all over the world and are responsible for a large number of deaths every year. Factors such as alcohol consumption, unhealthy lifestyle, viral infections, excessive use of medicines, and environmental pollution can damage the liver and disturb its normal functions. Since many synthetic drugs used for liver disorders may cause side effects after long-term use, researchers and healthcare professionals are now showing greater interest in medicinal plants as safer and more natural alternatives. Among these medicinal plants, Buchanania lanzan, commonly known as chironji, has gained significant attention because of its traditional medicinal value and therapeutic potential. For many years, different parts of this plant have been used in traditional Indian medicine for the treatment of various diseases. Among all parts, the seeds are considered especially important because they are rich in nutrients and several bioactive compounds such as flavonoids, phenols, tannins, saponins, and fatty acids. These natural compounds are well known for their antioxidant and protective properties, which help the body fight against harmful free radicals and oxidative stress. Since oxidative stress is closely linked with liver damage and weakened immunity, the antioxidant activity of Buchanania lanzan plays an important role in maintaining overall health. In this review paper, we discussed how different extracts of Buchanania lanzan show antioxidant, anti-inflammatory, immunomodulatory, and hepatoprotective activities. Studies suggest that the plant helps strengthen the immune system, reduce inflammation, and protect liver cells from toxin-induced damage by improving liver enzyme levels and restoring normal liver function. Because of these beneficial effects, Buchanania lanzan may become a promising natural medicine for liver and immune-related disorders. However, despite its encouraging medicinal potential, more detailed experimental and clinical studies are still required to confirm its safety, effectiveness, and future pharmaceutical applications.

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