World Journal of
Pharmaceutical and Life Sciences

REVISITING GUILLAIN-BARRE SYNDROME: AYURVEDIC PATHOGENESIS AND PANCHAKARMA-BASED MANAGEMENT

Mishra Kumari Kirti*, Vikram Kumar

ABSTRACT

Background: Guillain-Barre Syndrome (GBS) is an acute, immune-mediated peripheral polyneuropathy characterized by progressive ascending paralysis, sensory deficits, areflexia, and in severe cases, respiratory failure. Though modern medicine employs intravenous immunoglobulin therapy and plasmapheresis for acute management, complete recovery remains elusive in many patients and long-term rehabilitation support is limited. Ayurveda, the ancient Indian system of medicine, does not explicitly name GBS; however, its clinical manifestations closely resemble the condition described as Sarvangavata (Vata disorder affecting the entire body) within the broader framework of Vatavyadhi (disorders caused by vitiated Vata dosha). The Panchakarma system of bio-purificatory therapies offers a structured, individualized approach to the management of such neuromuscular disorders. Aim: To review and compile the Ayurvedic understanding of Guillain-Barre Syndrome with emphasis on its conceptual correlation as Sarvangavata, its pathogenesis through Samprapti Ghataka, dosha-dhatu-srotas involvement, and the role of Panchakarma in its comprehensive management. Materials and Methods: This is a narrative review based on classical Ayurvedic textual references from Charaka Samhita, Sushruta Samhita, Ashtanga Hridayam, and Ashtanga Sangraha, along with published peer-reviewed case studies and review articles on GBS management in Ayurveda. Relevant sections pertaining to Vatavyadhi Chikitsa, Sarvangavata, Pakshaghata, Avarana, and Panchakarma, reviewded. Results and Observations: GBS demonstrates a clinical presentation closely mirroring the Ayurvedic description of Sarvangavata with features of Kaphavruta Vyana, Pittavruta Vyana, and Majja Dhatu Dushti. The pathogenesis begins with Agnimandya (impaired digestive fire), leading to Ama formation, progressive Srotorodha (channel blockade), and culminating in Dhatukshaya with predominant Vata aggravation. Panchakarma procedures including Snehana, Swedana, Basti, Virechana, Nasya, and Shasthikashali Pindasweda have demonstrated significant symptomatic improvement and functional recovery in published clinical cases. Conclusion: Guillain-Barre Syndrome can be effectively managed within the Ayurvedic framework of Sarvangavata Chikitsa and Avaranajanya chikitsa and by Panchakarma. The integration of classical bio-purificatory procedures with nourishing Rasayana therapy and individualized Pathya-Apathya (dietetics) offers promising outcomes in neurological rehabilitation and may significantly enhance quality of life in GBS patients.

[Full Text Article]   [Download Certificate]