World Journal of
Pharmaceutical and Life Sciences

FORMULATION AND EVALUATION OF CLINDAMYCIN PHOSPHATE AND METHYLGLYOXAL CO-LOADED TRANSFERSOMAL GEL FOR TOPICAL ANTIMICROBIAL DELIVERY

Mohammed Mafaz K.*, Saranya P., Lakshmipathi G., Anusiya C., Vimal P., Mr. V. Parthasarathi

ABSTRACT

The present study developed and evaluated an egg yolk lecithin-based transfersomal gel co-loaded with
clindamycin phosphate and methylglyoxal for topical antimicrobial delivery. Five transfersome formulations were
prepared by thin-film hydration using Tween 80 as edge activator and citrate buffer as the hydration medium. The
optimized formulation (F4) showed a particle size of 184 ± 5 nm, polydispersity index of 0.24 ± 0.01, zeta potential
of −31.2 ± 0.9 mV, and entrapment efficiency of 87.9 ± 1.1% for clindamycin phosphate and 70.4 ± 1.3% for
methylglyoxal. The formulation exhibited sustained release over 24 h and produced greater antimicrobial activity
against Staphylococcus aureus and Cutibacterium acnes than single-drug transfersomes, free drug combination, and
marketed clindamycin gel. The optimized dispersion was incorporated into an HPMC gel with acceptable pH,
viscosity, spreadability, extrudability, and drug content uniformity. Short-term refrigerated stability was
satisfactory. The study supports co-loaded transfersomal gel as a promising topical system for acne-associated
antimicrobial therapy.

[Full Text Article]   [Download Certificate]