World Journal of
Pharmaceutical and Life Sciences

A COMPREHENSIVE REVIEW OF MEDICINAL PROPERTIES & PHARMACOLOGICAL RESEARCH OF GYPSOPHILA PANICULATA LINN

Dr. Sundhararajan R., Sanjukta Sainath Singh*, K. Gayathri

ABSTRACT

Gypsophila paniculata L., commonly known as baby’s breath and belonging to the Caryophyllaceae family, has
long been utilized in traditional medicine for managing respiratory, digestive, and metabolic conditions. This
review summarizes existing information on its ethnomedicinal relevance, chemical constituents, and biological
activities. Phytochemical studies have identified several important compounds, including triterpene saponins
(particularly gypsogenin-based derivatives), flavonoids, phenolic compounds, glycosides, and fatty acids, which
are believed to contribute to its medicinal effects. Various experimental models have demonstrated notable
antioxidant potential, evaluated through assays such as DPPH, FRAP, and nitric oxide scavenging, largely linked to
its polyphenol content. Animal studies also suggest significant antidiabetic properties, including lowering of blood
glucose levels, improvement in lipid metabolism, and reduction of oxidative stress, with effects comparable to
established drugs like metformin. Furthermore, the plant has shown anti-inflammatory activity by influencing
inflammatory mediators and regulating NF-κB signaling pathways. Additional studies indicate hepatoprotective
and lipid-lowering effects, supporting its possible role in treating metabolic disorders. Findings from other species
within the Gypsophila genus point to additional activities such as cytotoxic, neuroprotective, and anti-obesity
effects. However, detailed toxicity studies and clinical evidence remain insufficient. Therefore, although G.
paniculata shows promise as a source of therapeutic agents, further investigations focusing on mechanisms of
action, standardization, and safety are necessary before clinical application.[1,2,3,4,5,6,7]

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