World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

THE ROLE OF TREG CELLS IN IMMUNE EVASION IN TUMOR MICROENVIRONMENT

Tamalika Paul*

ABSTRACT

The tumour microenvironment (TME) plays an important role in immune suppression, cancer progression, metastasis and therapy resistance. Among the different cellular components of the tumor microenvironment, Tregs comprise diverse, heterogeneous subsets. Tumour-infiltrating Treg cells consist of a phenotypically and functionally distinct subset and contribute to cancer prognosis and clinical outcomes. Treg cells are important immunosuppressors cells. Treg cells are key contributors to immune evasion because they suppress pro-inflammatory responses, induce metabolic disruption and promote metastasis within the tumour microenvironment. They inhibit the effector T cells' function. In this way, Treg cells establish immunosuppressive tumor microenvironment, thus enabling tumor immune evasion. So, understanding the Treg biology in tumour microenvironment is very crucial for designing potent cancer therapy. In this review, the role of Tregs in cancer progression and tumour microenvironment is discussed. It is also discussed that the therapeutic opportunities for targeting Tregs cells to promote anti-tumor immune responses and also clinical benefits.

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