World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL ISOXAZOLE DERIVED QUINOLINES

S. B. Ghodile*, P. T. Kosankar, R. D. Raut

ABSTRACT

A series of diversely substituted Isoxazole derived quinoline (4a-g) were obtained by the reaction of various chalcones (3a-g) with hydroxylamine hydrochloride and sodium acetate in ethanol. New compounds were characterized by FT-IR, 1H- NMR and Elemental analysis. Antibacterial and antifungal activities of those compounds were determined by disc diffusion method against A. niger, A. flavus (fungal strains), E. coli and P. aeruginosa (Gram negative bacteria), S. aureus and S. pyogenes (Gram positive bacteria) using Nystatin (for fungi) and Ciprofloxacin (for bacteria) as a standard drugs. The in vitro antifungal and antibacterial screening of the isoxazole derived quinoline (4a-g) revealed that most of the compounds in the series showed potent activity.

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