World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

SIMULTANEOUS QUANTIFICATION, METHOD DEVELOPMENT AND METHOD VALIDATION FOR LOSARTAN POTASSIUM AND ENALAPRIL MALEATE IN SOLID DOSAGE FORM BY RP-HPLC

S. Teja*, A. Kanaka Durga Valli, P. Prathyusha, K. Bindu Latha, M. Sravanthi

ABSTRACT

Analytical Method Validation is crucial in pharmaceutical research and manufacturing process. Losartan Potassium
and Enalapril Maleate Peaks were well resolved at retention times 9.604 and 2.604 min respectively for 1ml/min
flow rate in isocratic mode at a run time of 15 min with Welchrom 250mm x 4.6mm, 5μm column & Ammonium
acetate buffer: water: methanol (10:30:60) as mobile phase at 226nm. % Assay values were 99.52% and 99.15%
for Losartan potassium and Enalapril maleate respectively. Linearity was produced in the range of 24-72 ppm for
Losartan Potassium and 20-60 ppm for Enalapril Maleate with a correlation coefficient of 0.9993 & 0.9998
respectively. The new approach was verified using ICH requirements and found to be specific, sensitive, precise,
reliable, and linear. The suggested approach may successfully estimate Losartan Potassium and Enalapril Maleate
in marketed formulations.

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