World Journal of
Pharmaceutical and Life Sciences

A REVIEW ON APPLICATION OF HYDROTROPIC SOLUBILIZATION IN THE ESTIMATION OF POORLY SOLUBLE DRUGS IN BULK AND PHARMACEUTICAL DOSAGE FORM BY SPECTROPHOTOMETRY

Remi S. L., Abhijith Jayan*, Amegha C. S., Devika B. S., Muhammed Shan C. V., Sivanandini S. Babu

ABSTRACT

Solubility of different drug formulations depends on various factors like temperature, pressure, degree of ionization, partition coefficient, nature of solvents, etc. Solubility is a vital factor for the estimation of drugs or any chemical entity. Estimation of poorly soluble drugs depends upon their solubility in different solvents. Literature survey tells us that spectroscopic estimation of poorly soluble drugs is mostly done by using organic solvents. The main limitation of using organic solvents for the estimation is that they are highly toxic, expensive, cause pollution and result in bias due to their volatile nature. Hence different methods of solubilization techniques can be utilized to improve the solubility of poorly soluble drugs in water. One such cost-effective and novel method is hydrotropic solubilization technique, which involves increasing the solubility of poorly soluble drug candidate in water by the addition of hydrotrope. The review emphasizes the mechanism of hydrotropic solubilization, what are the novel methods employed, different hydrotropes used, advantages over conventional techniques and also validation of the method by ICH guidelines. By utilizing hydrotropic solubilization technique, spectroscopic estimation of poorly soluble drugs can be easily analyzed.

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