World Journal of
Pharmaceutical and Life Sciences

NEUROTOXICOLOGICAL ALTERATIONS INDUCED BY CADMIUM: AMELIORATIVE AND THERAPEUTIC APPROACH OF ALLIUM SATIVUM AND LYCOPERSICON ESCULENTUM

Puttaganti Vijaya*, Suman Sharma

ABSTRACT

Cadmium (Cd) is a heavy metal and during its extraction process, it gets accumulated into the atmosphere, hydrosphere and even soil, thereby contaminating human environment. The present study was aimed to investigate the cadmium induced damage in some biochemical parameters and the histomorphological changes in adult mice brain along with the protection afforded by the Allium sativum and Lycopersicon esculentum. Albino mice were divided into several experimental groups and were given single dose of cadmium followed by natural antioxidants i.e. garlic and tomato extract for 45 and 90 days under protective and therapeutic study. At the end of the experiment, the levels of lipid peroxidation were increased while and SOD, CAT, and GST activities along with AChE levels were decreased in cadmium treatments. There was significant decline in the glycogen, cholesterol and total proteins in brain of cadmium treated group as compared to control value. Cadmium induced many pathological changes in the form of vacuolation, hyperemia, necrosis along with pyknotic cells and binucleated cell formation in both cerebral cortex and hippocampal regions of brain. Thus, the result indicated that cadmium induced oxidative stress may be the cause of ultrastructural disturbances in the brain tissue. But, the antioxidant potential of both garlic and tomato along with their constituents afforded significant protection in biochemical and histopathological changes against cadmium toxicity.

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