World Journal of
Pharmaceutical and Life Sciences

IDENTIFICATION OF BIOACTIVE PHYTOCHEMICALS IN THE METHANOLIC EXTRACT OF SOLIVA SESSILIS WITH POTENTIAL APPLICATION IN DIABETIC WOUND HEALING

Mnahil Mohamed Gamal*, Mohammed Suleiman Ali Eltoum, Mai Makki

ABSTRACT

The identification of bioactive phytochemicals from medicinal plants is essential for the discovery of novel therapeutic agents, particularly for the management of chronic diseases such as diabetic wounds. The present study aimed to investigate the phytochemical composition of the methanolic leaf extract of Soliva sessilis using gas chromatography-mass spectrometry (GC-MS) and Fourier transform infrared (FTIR) spectroscopy. Leaves of S. sessilis were extracted with 85% methanol, and resulting extract was subjected to GC-MS analysis. A total of 154 phytochemical constituents were detected, including fatty acids, esters, flavonoids, phenolic compounds, and alcohols. The major compounds identified were hexadecenoic acid hexadecyl ester and hexadecanoic acid octadecyl ester (19.10%), followed by 1-hexadecanol acetate (13.04%) and hexadecanol (9.90%). Many of these compounds have been reported to possess antimicrobial, antioxidant, and anti-inflammatory activities, which are crucial mechanisms involved in diabetic wound healing. FTIR analysis further confirmed the presence of key functional groups associated with these bioactive compounds. The findings provide scientific evidence supporting the traditional use of Soliva sessilis and highlight its potential as a natural source of bioactive agents for pharmaceutical applications in diabetic wound management.

[Full Text Article]   [Download Certificate]