World Journal of
Pharmaceutical and Life Sciences

TOXIC IMPACT OF FLUBENDIAMIDE ON LIPID PEROXIDATION IN THE LIVER AND BRAIN OF FRESHWATER FISH LABEO ROHITA

*Dr. Sneha Sampatrao Desai

ABSTRACT

The widespread use of the diamide insecticide flubendiamide in modern agriculture has raised concern about its potential toxicity to non-target aquatic organisms. The present study investigates the acute (96 hr) effects of flubendiamide on lipid peroxidation in the liver and brain tissues of the freshwater fish Labeo rohita. Fingerlings were divided into three experimental groups Control, LC?, and LC?? and exposed to the predetermined concentration of flubendiamide for 96 hrs under controlled laboratory conditions. Lipid peroxidation was assessed by estimating malondialdehyde (MDA) content, a key biomarker of oxidative stress. Results revealed a significant, concentration-dependent increase in MDA levels in both liver and brain tissues compared to controls, confirming the induction of oxidative stress. These findings demonstrate that even short-term exposure to flubendiamide can disrupt redox homeostasis and enhance lipid peroxidation in L. rohita. Hence, uncontrolled use of flubendiamide near aquatic environments may pose ecological risks to fish and other aquatic organisms. The study emphasizes the need for careful monitoring and regulation of pesticide runoff and recommends further investigations on chronic exposure and antioxidant defense mechanisms.

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