World Journal of
Pharmaceutical and Life Sciences

OPTIMIZATION AND CHARACTERIZATION OF A CURCUMIN NANOEMULSION USING A 2³ FACTORIAL DESIGN

C. Sadak Vali*, Abdullah Khan, Reddy Nazemoon, Mare Pratibha Bharathi, S. Siva Prasad, Survi Swati Goud

ABSTRACT

The present study was aimed to optimize and characterize a curcumin nanoemulsion using a 2³ factorial design to improve its solubility, stability, and bioavailability. Curcumin nanoemulsions were prepared using oil (Capryol 90), surfactant (Tween 80), and co-surfactant (PEG 400) as key formulation variables. The effects of oil (X?), surfactant (X?), and co-surfactant (X?) concentrations were evaluated on particle size (Y?), polydispersity index (PDI, Y?) and entrapment efficiency (%EE, Y?). The factorial design was analyzed using Design Expert software. The optimized nanoemulsion exhibited a droplet size of 140.3 ± 2.4 nm, PDI of 0.172, zeta potential of −30.8 mV, and %EE of 90.6 ± 1.8%. Statistical analysis showed that surfactant and co-surfactant concentrations significantly influenced the droplet size and stability (p < 0.05). The 2³ factorial design effectively optimized curcumin nanoemulsion formulation parameters, yielding a stable and efficient system suitable for enhancing oral bioavailability.

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