World Journal of
Pharmaceutical and Life Sciences

CAUSES SYMPTOMS OF AUTISM SPECTRUM DISORDER: THEIR ATTENUATION BY A MICRONUTRIENT MIXTURE, PROBIOTICS WITH PREBIOTICS, COLLAGEN PEPTIDES, OMEGA-3, DIGESTIVE ENZYMES, AND CANNABIDIOL (CBD)

Kedar N. Prasad*

ABSTRACT

Autism spectrum disorder (ASD) is a group of complex brain development disorders which include autism and Asperger’s syndrome (AS). The prevalence of ASD was 3.2% among children aged 8 years, and it was higher among boys (4.92%) than girls (1.43%). It was higher among children of black Americans, Asian/Pacific Islanders. Native Indian, and Alaska natives than white Americans. Although genetic causes of ASD are certain; however, the impact of environmental factors and drug use during pregnancy remain uncertain. Therefore, no prevention plan for ASD can be developed at this time. The annual national cost of ASD was $41.8 billion. Since the symptoms of ASD and their causes are well defined, we have proposed an effective plan to improve current treatments of symptoms. Causes of symptoms of ASD include increased oxidative stress, chronic inflammation, elevation of glutamate and reduction in GABA levels, deficiency of serotonin and dopamine. Other internal stressors which participate in the development and maintenance of ASD symptoms include intestinal dysbiosis, dysfunctional onega-3, deficiency of gut generated GLP-1 due to increase activity of enzyme DPP-4 that degrades GLP-1, and digestive enzymes. We suggest consuming daily proposed micronutrient mixture which would simultaneously reduce oxidative stress and chronic inflammation, CBD which would reduce glutamate level and incases GABA level, and restore serotonin and dopamine levels, probiotics with prebiotics which would reverse the harmful effects of intestinal dysbiosis on the symptoms, Omeg-3 which would replace dysfunctional omega-3, Collagen peptides which have Amla and white tea extracts that have inhibitors of the enzyme DPP-4 which degrades GLP-1 and thereby maintain high level of GLP-1, and digestive enzyme to restore normal level of digestive enzymes

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