World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

6-GINGEROL FOR CANCER THERAPY- AN IN SILICO APPROACH

Manikesh Kumar*, Priyanka James, M. R. Shylaja and P. A. Nazeem

ABSTRACT

The natural polyphenolic alkanone 6-gingerol, a major pharmacologically active component of ginger has anti-inflammatory and antitumoral properties. Its potent anti-tumor activity has been reported in a variety of cancer types, including breast, pancreatic, gastric, colon and colorectal cancer and certain hematological malignancies. In a cellular milieu, binding of 6-gingerol with a protein could suppress the cancer cell growth and affect the dynamics of protein-protein interaction thereby altering the structure and function of the protein. In the present study, we identified the potential binding proteins of 6- gingerol for various types of cancer. 6-gingerol was docked to targets – epidermal growth factor receptor (EGFR), oestrogen receptor (ER), Cyclooxygenases (COX-2), Cyclin-dependent kinases (CDKs), and p90 ribosomal protein kinase 2 (RSK2) with the Docking software Discovery studio and docking based virtual screening was attempted.

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