World Journal of
Pharmaceutical and Life Sciences

PREPARATION AND CHARACTERIZATION OF MICROEMUL GEL CONTAINING COMBINE DRUGS AND ITS ANTIMICROBIAL ACTIVITY

Shubham Kumar Sharma*, Ganesh Prasad Patel, Hemant Agarwal, Naveen Gupta

ABSTRACT

Pre-formulation studies were conducted to evaluate the fundamental characteristics of the drug, including organoleptic properties, solubility, melting point, pH, λ max, and functional groups through FTIR analysis. A calibration curve was developed for precise drug quantification. Based on these findings, a microemulsion containing the drug was successfully formulated and characterized for encapsulation efficiency, zeta potential, particle size distribution, and surface morphology using SEM. Subsequently, a microemulgel formulation was prepared and evaluated for pH, viscosity, spreadability, skin irritation, and in vitro drug release behavior. The release kinetics were analyzed to understand the drug’s release profile. Furthermore, antimicrobial activity was assessed using the well diffusion method, confirming the formulation’s efficacy against microbial strains. Overall, the results indicated that the formulated microemulgel exhibited desirable physical stability, efficient drug release, and promising antimicrobial potential, making it a suitable candidate for topical drug delivery applications.

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