World Journal of
Pharmaceutical and Life Sciences

ANTHELMINTICS DRUGS USED IN TRATEMENT OF PARASITE INFECTION CAUSED BY HELMINTHS

*Jathar Suyog, Jaykar Sayali, Dr. Ashiwni Aswar

ABSTRACT

Recent advancements in parasitology have led to the discovery of new drug targets for anthelmintic therapy, including ion channels, neuromuscular junctions, and metabolic enzymes unique to helminths. Commonly used drugs such as albendazole and mebendazole function by inhibiting microtubule formation, effectively starving the parasites by blocking glucose uptake. However, the growing incidence of anthelmintic resistance, especially in livestock and endemic regions, has raised concerns over treatment efficacy. This has prompted research into combination therapies and novel drug candidates derived from natural products, such as plant alkaloids and marine peptides. Additionally, RNA interference (RNAI) and CRISPR gene editing are being explored in experimental models to better understand parasite biology and identify resistance mechanisms. These strategies represent promising directions for the development of next-generation anthelmintic agents.

[Full Text Article]   [Download Certificate]