World Journal of
Pharmaceutical and Life Sciences

KHINDIVI A HYDROCORTISONE DRUG

Dr. R. Jona Methusala*, S. Sai Varsha

ABSTRACT

Khindivi (Oral Solution of Hydrocortisone) Khindivi is an oral hydrocortisone formulation designed specifically for children with adrenocortical insufficiency who are five years of age or older. Khindivi, a synthetic glucocorticoid, supports immunologic, metabolic, and stress-response processes by restoring low cortical levels. The formulation, which is designed for age-specific titration and variable dosage, provides 1 mg/mL hydrocortisone in a glycerin-based solution. Since Khindivi is not authorized for stress dosage during acute events, unlike other hydrocortisone medications, alternate corticosteroid therapies are required in emergency situations. In order to replicate the diurnal cortical rhythm, clinical use requires customized dose based on body surface area (8–10 mg/m²/day), split into two or three administrations. Adverse reactions include hepato-renal issues, central nervous system toxicity, and metabolic acidosis, particularly in individuals who are hypersensitive to excipients like propylene glycol and polyethylene glycol 400. Khindivi's pharmacokinetic profile and tolerability underscore its importance in long-term endocrine therapy; cautious monitoring is required to avoid adrenal crisis during formulation changes or stressful situations.

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