World Journal of
Pharmaceutical and Life Sciences

FORMULATION AND INVITRO CHARACTERIZATION OF FLUVOXAMINE LOADED NANO PARTICLES

CH. Saibabu*, Midisala Srija

ABSTRACT

The real challenge in the development of a controlled drug delivery system is not just to control the drug release, also to extend the existence of the dosage form in the absorption site until all the drug is completely released in the preferred period of time. Nanoparticulate carriers may provide a better therapeutic output by targeting drugs specifically to their site of action and by improving the pharmacokinetic profile of effective drugs low bioavailability and low half-life. In present inviuestigation Nanoparticles were prepared by emulsification method. New Nanoparticulate drug carrier that combines the benefits of polymeric nanoparticles to enhance the bioavailability of drugs, retain the drug in the absorption site more than the half-life of the drug, reduce dose frequency, toxicity and patient compliance. Total nine nanoparticles formulations was formulated using Ethyl cellulose, Eudragit RS 100 & Eudragit RL 100. The drug release from the Nanoparticles was explained by the using mathematical model equations such as zero order, first order, and equation methods. Based on the regression values it was concluded that the optimized formulation F6 follows Zero order drug release with super case II transport mechanism.

[Full Text Article]   [Download Certificate]