World Journal of
Pharmaceutical and Life Sciences

REVIEW LITERATURE: RELATIONSHIP BETWEEN KNOWLEDGE, ATTITUDE, SOCIETY ABOUT THE BEHAVIOR OF RATIONAL USE OF ANTIBIOTIC SELF-MEDICATION IN COMMUNITY HEALTH CENTER

Antonio Ximenes*, Joaquim Pinto, Sancha Liliana Maria dos Santos, Isabel Barotolumeu Freitas, Remígia Auxiliadora de Jesus Ximenes, Saturnina Julieta Geri de Sena Amaral

ABSTRACT

Background: Irrational use of antibiotics is a global health problem, triggering antimicrobial resistance (AMR). Knowledge, attitudes, and practices (KAP) of health workers and the community play an important role in determining the rationality of antibiotic use. Objective: This review analyzes 20 studies on knowledge, attitudes, and practices of health workers, doctors, pharmacists, and the community related to antibiotics in Indonesia and other countries, to map trends, associated factors, and intervention recommendations. Methods: Cross-sectional review with a quantitative survey approach on 20 national and international published articles (2008–2023). Data extracted include design, location, sample size, knowledge, attitudes, practices variables, and key results. Results: Doctors' and community knowledge varies; attitudes tend to be good but not always in line with practice; system factors (regulation, training, availability of guidelines) influence behavior. Multifaceted interventions are needed to improve rationality. Conclusion: Knowledge, attitudes, and practices related to antibiotics need to be improved through education, policies, and drug use audits. Cross-sector collaboration is needed to reduce AMR.

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