World Journal of
Pharmaceutical and Life Sciences

DETRIMENTAL INFLUENCE OF CYPERMETHRIN EXPOSURE ON BLOOD INDICES AND BIOCHEMICAL PARAMETERS IN ALBINO RAT

Saeed A. Alwaleedi*

ABSTRACT

Cypermethrin is a synthetic pyrethroid insecticide, which is effective against a wide variety of pests. It is widely used in agriculture, public health, and household pest control. However, cypermethrin has many harmful impacts on non-target organisms. This investigation aimed to examine the deleterious impacts which may result from exposure to sub-lethal doses of cypermethrin on body weight, haematological and biochemical parameters, liver and kidney function. The experimental animals were divided into four groups (n=40). The first one served as healthy control animals, while groups II, III, and IV received sub-lethal doses of cypermethrin in drinking water for 60 days. Blood was collected and used for haematological and biochemical analysis. The results revealed that animals received cypermethrin indicated a significant decrease in TEC, PCV, Hb, MCV, MCH and MCHC. While there was remarkable elevation in TLC and platelets. The data also revealed a considerable increase in serum levels of ALT, AST, GGT, ALP, and LDH indicating liver impairment. Moreover, the serum concentration of BUN and creatinine was also elevated, indicating nephropathy. Treatment with cypermethrin has deleterious impacts on experimental animals and induced haematological and biochemical changes. Consequently, this investigation recommends people to intercept any exposure to this toxic chemical to avoid its harmful effects on health and environment.

[Full Text Article]   [Download Certificate]