World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

GC-MS ANALYSIS AND ANTIMICROBIAL ACTIVITY OF CURCUMA LONGA L. (ZINGIBERACEAE) FIXED OIL

Abdel Karim. M.*, Abdel Wahab,A. Osman

ABSTRACT

This study was set to investigate the chemical constituents of the medicinally important species Curcuma longa fixed oil and to evaluate its potential antimicrobial activity.61 components were detected by GC-MS analysis being dominated by: 2-(2-phenyl-2-propyl)-1,3-dioxolane(15.5%), 5-(4-ethylphenyl)-imadazole-4-propenoic acid(7.51%), 2-methyl-3-trimethylsilyl-1,3,7-octatriene(7.31%), curlone(5.80%), 9,12-octadecadienoic acid methyl ester (5.47%), hexadecanoic acid methyl ester(4.73%) and methyl stearate(3.66%). In cup plate agar diffusion bioassay, the oil exhibited excellent activity against Bacillus subtilis at concentrations: 25-100 mg/ml. It also showed activity against all test organisms in this range of concentration, but it was inactive against Staphylococcus aureus at 25mg/ml. At a concentration of 12.5mg/ml it showed activity only against Pseudomonas aeruginosa and Escherichia coli.

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