World Journal of
Pharmaceutical and Life Sciences

CASE STUDY ON PREDNISOLONE INDUCEDGASTRITIS, CANDIDIASIS AND STOMATITIS

*Salome Satyavani P, and Mounika Goud. P.

ABSTRACT

Chronic administration or use of steroids have a lot of side effects like cushing syndrome, gastritis, glossitis, angioedema, avascular necrosis, bradycardia, candidiasis, glossitis and cardiomyopathy etc. Prednisolone is a glucocorticoid drug which is indicated in SLE, asthma, ulcerative colitis and in inflammatory condition. The usual dose of Prednisolone in SLE is 5mg per day. Normal serum cortisol level is 10 to 20 ug/dl. Here is the case of 31 year old female patient who is suffering from gastritis, candidiasis, glossitis and stomatitis caused by chronic use of Prednisolone. She is a known case of SLE since one and half year and she is taking Prednisolone 10mg TID since 1 year and 5mg BD 3 months back. She has complaints of loose stools since 3days associated with Mucus and blood (several episodes), fever (102F), Nausea, vomiting, general weakness, Bp-100/70 mmhg, cardiomyopathy, oral candidiasis, oral ulcers, difficulty swallowing, erythematous rash all over oral cavity, sore throat. She was treated with (racecadotril), probiotics and PPI and monitoring of serum cortisol level is necessary in this case and withdrawl of drug was done in this case. Advising the patients regarding the side effects of Prednisolone and life style modifications such as diet with yoghurt and patient should undergo regular medical checkups to assess the effect of steroid in the body. By monitoring of serum cortisol levels we can avoid the toxicity.

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