World Journal of
Pharmaceutical and Life Sciences

GC-MS ANALYSIS AND ANTIMICROBIAL ACTIVITY OF CITRULLUS COLOCYNTHIS [1,2,10] SEEDS OIL

Mohamed Yousif Mustafa*

ABSTRACT

The study investigated the chemical composition of Citrullus colocynthis[1,2,10] seed oil using GC-MS analysis and evaluated its antimicrobial activity against various pathogenic microorganisms. The GC-MS analysis revealed the presence of twenty components, including 9,12-octadecadienoic acid (Z,Z)-, methyl ester (48.68%), methyl stearate (13.32%), hexadecanoic acid, methyl ester (13.25%), octadecanoic acid (7.53%), methyl ester (5.42%), cyclopropaneoctanal, 2-octyl- (4.53%), and cyclopropaneoctanal, 2-methyl- (2.33%). The oil exhibited significant antimicrobial activity against all tested microorganisms, including Staphylococcus aureus in the concentration range 100–25 mg/ml, Bacillus subtilis in the concentration range 100–25 mg/ml, Pseudomonas aeruginosa in the concentration range 100–25 mg/ml, Escherichia coli in the concentration range 100–50 mg/ml, and Candida albicans in the concentration 100 mg/ml.

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