World Journal of
Pharmaceutical and Life Sciences

COMPATIBILITY STUDIES OF SULFADOXINE WITH PHARMACEUTICAL EXCIPIENTS FOR THE DEVELOPMENT OF SUPPOSITORIES NOVEL DRUG DELIVERY SYSTEMS

Mahmoud Mahyoob Alburyhi*, Abdalwali Ahmed Saif, Maged Alwan Noman

ABSTRACT

The main objective of the present study was to the preformulation studies were performed to know the development of formulation and evaluation of Sulfadoxine antimalarial drugs in formulated suppositories Drug Delivery Systems. Sulfadoxine is classified as a biopharmaceutics classification system (BCS) Class-I. Preformulation, formulation and evaluation of Sulfadoxine to avoid problems associated with conventional delivery system such as limited permeation, low dissolution and bioavailability and also to improve bioavailability and one of the most antimalarial agents. In the present study that the compatibility was assessed by, FTIR spectroscopy, and melting point apparatus, precompression parameters. Results showed that physical mixtures of antimalarial and various excipients as PEG4000 base, Cocoa butter and Witepsol H35 were evaluated for preformulation studies parameters. It was concluded that the drug Sulfadoxine was found to be compatible with various excipients which were selected for the formulation development of the Sulfadoxine antimalarial drug in formulated suppositories Drug Delivery Systems. Formulation scientist from his experience and knowledge have to significantly in the preformulation study stage and is an important factor in the ADDS (Advanced Drug Delivery Systems) product development process.

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