World Journal of
Pharmaceutical and Life Sciences

FABRICATION OF MICRONEEDLE PATCH FOR TRANSDERMAL DRUG DELIVERY USING 3D PRINTING TECHNOLOGY

Gopika Jayan J. S.* and Santy Rose P.

ABSTRACT

Transdermal drug delivery system offers an alternative system to traditional needle injection method by improving the challenges such as low drug permeation, first-pass metabolism, low complains and patient discomfort. Among TDDS, microneedle (MN) patches standout as a highly promising, non-invasive technique which contain micron sized needle that can temporarily disrupt stratum corneum layer and enable precise and enhanced drug permeation. The conventional microneedle fabrication methods like micro-molding, micro-machining are effective but often lack design specificity and flexibility. To overcome this, a simpler, cost-effective and highly customizable approach called Three-Dimensional (3D) printing technology has revolutionized for MN fabrication. The review provides a comprehensive summary of the mechanism of drug delivery via MN patch, various types of microneedles with its unique benefits. The article mainly highlights the requirements for development of MNs using additive manufacturing technology and its various type. Additionally, the review addresses the diverse application and critical challenges in MN fabrication.

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