World Journal of
Pharmaceutical and Life Sciences

A REVIEW ON THIOPHENE-BASED HYBRIDS: ADVANCES IN SYNTHESIS AND MULTITARGET PHARMACOLOGICAL APPLICATIONS

Priya A.*, Mahesh Kumar N. and Dr. Shachindra L. Nargund

ABSTRACT

Recent advancements in medicinal chemistry have underscored the versatility of heterocyclic frameworks,
particularly thiophene, in the pursuit of novel therapeutic agents. Thiophene-based hybrids are increasingly
recognised as dynamic platforms for innovation, as scientists strategically merge the thiophene core with other
bioactive motifs to construct multifunctional drug candidates. This hybridisation approach responds directly to
modern demands: improved selectivity, reduced toxicity, and the ability to address complex diseases through multitarget
mechanisms. Groundbreaking synthetic methods such as click chemistry, green synthesis, and AI-driven
molecular design now play pivotal roles in tailoring thiophene hybrids for enhanced pharmacological properties.
Current research extends far beyond traditional applications, with thiophene hybrids showing promise in fields
such as oncology, antimicrobial therapy, neurodegeneration, and metabolic disorders. Furthermore, drug
repurposing and fragment-based drug design have accelerated the identification of new thiophene-based hybrids
with clinically relevant functionality. This review consolidates contemporary strategies and therapeutic outcomes,
highlighting how innovative approaches to thiophene-based hybrids are redefining the frontiers of drug discovery.
As the integration of computational and experimental methods deepens, thiophene hybrids stand at the forefront of
next-generation medicinal chemistry, offering new hope for challenging medical conditions.

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