World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

TRANSDERMAL DRUG DELIVERY OF LAMOTRIGINE THROUGH LIPOSOME FOR CONTROLLED DRUG DELIVERY

Deepak*, Dr. Dharmendra Singh Rajput and Dr. Naveen Gupta

ABSTRACT

Liposomes, as the name indicates, they are little spherical shaped artificial vesicles prepared by using various phospholipids. With their hydrophobic, hydrophilic characters and smaller size, they actively deliver the drugs to site of action. The liposomal drug delivery system differs in their properties based on lipids composition, their preparation methods, size and surface charges. The selection of bilayer components determines the charge and fluidity of the vesicles. The permeable less stable bilayers of vesicles can be prepared using unsaturated phosphatidyl-choline species obtained from natural sources. The impermeable rigid bilayer structure is obtained using saturated phospholipids having long acyl chains. The aim of present study to prepare transdermal drug delivery of lamotrigine through liposome for controlled drug delivery.

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