World Journal of
Pharmaceutical and Life Sciences

FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES CONTAINING NIFEDIPINE

Vinod Babaleshwar*, Vitthal Vijapure and Rashmi Kolli

ABSTRACT

This study aims to develop and assess transdermal patches incorporating nifedipine, a well-established medication for controlling hypertension and managing angina pectoris. Transdermal drug delivery systems offer a means of releasing drugs in a controlled and sustained manner through the skin into systemic circulation, enhancing both patient compliance and therapeutic outcomes. In this work, patches were fabricated via the mercury substrate technique, utilizing different blends of polymers, along with a penetration enhancer and plasticizer. Five distinct formulations (F1 to F5) were prepared using a combination of hydrophilic (HPMC) and hydrophobic (Ethyl cellulose) polymers. To confirm formulation stability, drug-excipient compatibility was thoroughly investigated. Among all formulations, F5 exhibited the most favorable evaluation parameters, including suitable thickness, consistent weight, excellent folding endurance, and appropriate moisture uptake. These findings underscore the promise of transdermal patches as an effective approach for the sustained systemic delivery of nifedipine.

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