World Journal of
Pharmaceutical and Life Sciences

EFFECTS OF METHANOLIC BARK EXTRACT OF TRADITIONALLY USED MEDICINAL PLANT PHOEBE GOALPARENSIS HUTCH. ON SOME OF THE HEMATOLOGICAL PARAMETERS IN DALTON’S LYMPHOMA ASCITES INDUCED SWISS ALBINO MICE

*Merina Narah

ABSTRACT

Phoebe goalparensis Hutch. is an important medicinal plant used by the Mising tribe of Dhemaji District, Assam, to treat skin related ailments. The plant material was extracted using methanol as solvent. The methanolic bark extract of Phoebe goalparensis Hutch. (MBPG) was used for studying its effect on Dalton’s lymphoma ascites (DLA) tumorigenic swiss albino mice. The activity of MBPG was studied to observe its effect on hematological parameters-RBC (Red Blood Corpuscles), White Blood Corpuscles (WBC) and haemoglobin (Hb) content in DLA induced mice. Swiss albino mice of both sexes weighing 23-27 g were taken for the study. The experimental animals were divided into groups containing 4 mice (n=4) in each group. Two different doses of MBPG – 100 mg/kgbwt and 500 mg/kgbwt were taken for the study. Other groups constituted of DLA control, 5-Fluorouracil (5-FU)- 20 mg/kgbwt and Normal Control. The study showed that MBPG could significantly increase the Hb, RBC and decrease in WBC content in DLA induced swiss albino mice deciphering the efficacy of the plant extract.

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