World Journal of
Pharmaceutical and Life Sciences

PHARMACOLOGICAL EVALUATION OF CINNAMOMUM VERUM FOR THE ANTIDIABETIC ACTIVITY

Dr. Noorin Fatima* and Mehrukh Fatima

ABSTRACT

Background: The increasing prevalence of diabetes and related complications has prompted the exploration of alternative treatments. This study investigates the effects of an herbal formulation on various biochemical markers and its potential as a therapeutic agent for diabetes management. Aim: To evaluate the phytochemical properties, glucose-lowering effects, and safety profile of the herbal formulation in streptozotocin (STZ)-induced diabetic rats. Research Methodology: The polyherbal formulation was analyzed for moisture content, crude fiber, and ash values. Phytochemical screening revealed the presence of tannins, saponins, flavonoids, and alkaloids. The formulation was administered orally at different dosages, and its effects on fasting blood glucose (FBG), serum insulin levels, liver and renal profiles, and enzyme activities (alpha-glucosidase and alpha-amylase) were assessed over four weeks. Histopathological examinations were also conducted to evaluate organ integrity. Conclusion: The polyherbal formulation demonstrated significant reductions in FBG levels and improvements in serum insulin and enzyme activities, indicating its potential as an effective antidiabetic agent. The formulation also showed minimal adverse effects on liver and kidney functions. Histopathological analysis confirmed the therapeutic benefits. A promising candidate for diabetes management.

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