World Journal of
Pharmaceutical and Life Sciences

FORMULATION AND EVALUATION OF ANTI-BACTERIAL CREAM OF LABLAB PURPUREUS

D. Prathyusha*, A. Madhu Bindu, Vallepu Samatha, Dugane Ashok, Kunchala Navya Sri, Parvathi Harini, Chenchu Ramya

ABSTRACT

The study focuses on the formulation and evaluation of an herbal antibacterial cream using methanolic extract of Lablab purpureus (Hyacinth bean), a plant known for its wide range of pharmacological properties. The extract was prepared using both maceration and soxhlation methods, with soxhlation yielding a higher quantity of bioactive compounds. Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins and saponins, which are associated with anti-bacterial and therapeutic properties. A topical cream was formulated using the extract and evaluated for various parameters including pH, spread-ability, viscosity, homogeneity, washability and irritancy, all of which confirmed the formulations suitability for skin application. Anti-bacterial activity was tested using both cup plate method and disc diffusion method against Escherichia coli and Staphylococcus aureus. Results showed dose dependent anti-bacterial activity. The study concludes that Lablab purpureus extract can be effectively used in the development of the safe and natural topical anti-bacterial formulation.

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