World Journal of
Pharmaceutical and Life Sciences

A COMPARATIVE OBSERVATIONAL ANALYSIS OF BLOOD AND ASCITIC FLUID PARAMETERS IN THERAPEUTIC PARACENTESIS IN PATIENT WITH DIFFERENT LIVER DISEASE

Dr. Aashima Singh Chauhan*, Dr. Khushi Pathak, Dr. Shruti Rana, Dr. Pankti Dalwadi

ABSTRACT

Ascites is the abnormal accumulation of fluid in the peritoneal cavity, often treated with therapeutic paracentesis. This observational study aimed to compare pre-paracentesis blood parameters and the ascitic fluid, as significant research in this area is limited despite the frequent use of paracentesis for ascites in patients with various liver diseases. A total of 73 patients were enrolled in the study. Among them, males were more affected than females, comprising 81% of the participants, while females made up 19%. The age group most impacted was 61-70 years, accounting for 27% of the cases. Chronic liver disease emerged as the most common cause of ascites. Serum-Ascites Albumin Gradient (SAAG) values greater than 1.1 g/dL were observed in 90% of patients, indicating that transudative ascites is the predominant type. The variations across different liver disease and in normal cases were assessed using the Kruskal-Wallis test. This analysis revealed significant differences in Bilirubin, SGOT, and GGT indicating strong indicators of liver disease severity, especially in conditions like cirrhosis, ALD, and jaundice, with p-values of 0.0003, 0.0219, and 0.0136, respectively (p < 0.05). Platelet count also significantly correlates with disease severity, particularly in advanced liver diseases like cirrhosis and cancer with p value of 0.0328. Whereas other markers (creatinine, albumin, SGPT) show no significant variations across different liver diseases. Additionally, ascitic fluid analysis indicated significant differences in protein (p = 0.0200) and albumin concentrations (p = 0.0444). These findings highlight the importance of considering the underlying liver condition when interpreting results related to ascites which facilitates improved clinical practices and patient care.

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