World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

SYNTHESIS OF DERIVATIVES OF BETULINIC AND URSOLIC ACIDS ISOLATED FROM COMBRETUM GLUTINOSIUM PERR. EX DC (COMBRETACEAE) AND MORINDA GEMINATA DC (RUBIACEAE)

Aminata Thiam, Rokhyatou Seck, Armel Diatta, Anastasie Manga, Oumar Sambou, Siga Sagne, Emma Diatta, Michael Rivard and Abdoulaye Gassama*

ABSTRACT

Betulinic and ursolic acid isolated from the leaves of Combretum glutinosium Perr. Ex DC (Combretaceae) and Morinda geminata DC (Rubiaceae) have been used in fine chemistry. A coupling reaction with acid chlorides and/or HOBT has been successfully used for the synthesis of molecules derived from betulinic and ursolic acid. The semisynthesis of a set of small molecules derived from these promising compounds by pseudopeptide coupling is also reported. The obtained molecules were characterized by NMR and IR.

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